It’s Week 6, and we’re all a little traumatized. The injury bug has been so brutal this year that I’m convinced it’s keeping our own injury expert, Matthew Betz, fully employed. This week’s new admissions include Antonio Gibson, Omarion Hampton, and Brenton Strange. In most of my leagues, my IR spots are already filled, and my benches look like triage units. Meanwhile, players we crowned all offseason are flopping, and dudes we had written off (or literally retired…*cough* Darren Waller) are suddenly lighting it up. It’s a good reminder that in fantasy, the biggest edge isn’t clinging to preseason takes: it’s adapting. So before you tilt, panic-drop, or start rage-trading, take a breath. We’re going to sort through the toughest Start/Sit calls of Week 6 from the FootClan and stack those Ws together. Let’s get it!
Jaylen Waddle or Xavier Worthy?
This is the perfect “get-right” spot for the Chiefs’ passing attack. The Lions rank 6th against the run but just 26th versus WRs, allowing an average of 31.3 fantasy points per game to opposing WRs. It’s a full-blown pass-funnel defense. Although a lot of the Bengals’ production came in garbage time, their WR corps still dropped 49.4 fantasy points on Detroit last week. The Bears’ wideouts put up 42.4 fantasy points against them in Week 2. Vegas expects a high-scoring affair — the hefty 52.5-point total makes this the ideal matchup for fantasy gamers. Plus, Patrick Mahomes and company NEED this win, sitting at 2-3 and third in the division.
The BEST WR Matchups for Week 6:
– Davante Adams (BAL)
– Tetairoa McMillan (DAL)
– Xavier Worthy (DET)
– Matthew Golden (CIN)
– Deebo Samuel (CHI)
– Marvin Harrison Jr (IND)
– Rome Odunze (WAS)
– Michael Pittman Jr (ARI)— Chris O'Brien (@17gamepace) October 10, 2025
With Tyreek Hill out for the season, Jaylen Waddle is officially the guy in Miami. Last week, he backed it up. According to Marvin Elequin’s Expected Points & Opportunity breakdown, Waddle saw a 26.5% target share and a ridiculous 50.2% of the team’s air yards. That’s true WR1 usage, exactly what we’ve been waiting for. This week, the Dolphins face the Chargers in a game with a 44.5 over/under. Miami’s defense hasn’t stopped anyone lately, so expect them to stay aggressive through the air. The Chargers won’t make it easy, though; they have been one of the tougher defenses against wideouts, ranking 5th in fantasy points allowed to WRs. They also had six sacks just two weeks ago against the Giants. Tua is going to feel the pressure this week.
Verdict: Xavier Worthy. Vegas likes this game, and I do too. The O/U is too high to ignore, and it’s a must-win game for the Chiefs. The matchup for Waddle gives me pause. The Chargers know how to shut down offenses. They’ve allowed, on average, 19.6 points to opposing teams.
Jameson Williams or Kendrick Bourne?
It’s tough to trust Jamo right now. He played just 46% of snaps last week and saw one target. One. The Lions are spreading the ball around, and outside of his Week 2 outburst (17 points), he hasn’t topped five fantasy points in any other game. The matchup doesn’t exactly scream breakout either. Kansas City ranks 8th against WRs, allowing only 24 fantasy points per game to the position.
On the flip side, Kendrick Bourne‘s in a great spot. With Ricky Pearsall and George Kittle sidelined and Jauan Jennings still working back from injury, he’s basically the last healthy WR standing for San Francisco. He went off last week: 10 catches for 142 yards on 11 targets. Now, he faces a Bucs defense that’s middle of the pack against WRs (13th overall, 26.6 fantasy points allowed per game). Mac Jones has been limited this week but looks on track to play. Their chemistry from their time together in New England was prevalent last week. Bourne had a career-high mark in receptions last week. Even if Jennings is back, the Jones/Bourne connection shouldn’t fade.
Verdict: Bourne’s the play. Until Jamo earns consistent volume, he’s a pure dart throw. Bourne’s got the opportunity, the chemistry, and the matchup. The only wrinkle? If Mac Jones somehow doesn’t go and we’re rolling with third-string QB Adrian Martinez, pivot to Jamo and pray for a deep shot.
Michael Carter or TreVeyon Henderson?
Michael Carter handled 23 touches last week, turning them into 73 yards and a TD, but let’s be honest, it wasn’t exactly pretty. He’s averaging just 2.74 yards per carry, per Chris Cash in his Week 6 Matchups to Consider. The matchup this week doesn’t help either. Indy’s run defense ranks 7th, giving up only 16 fantasy points per game to opposing backs. If you’re starting Carter, you’re betting on volume and goal-line chance. If that usage slips and Emari Demercado or Bam Knight sneak in for more touches, you will be wishing you had pivoted. That said, after Demercado’s goal-line blunder and how the coaching staff reacted, Carter’s workload should be safe.
Meanwhile, over in New England, TreVeyon Henderson just cannot get consistent opportunity. Even with Rhamondre Stevenson coughing up the ball and Antonio Gibson leaving with an injury, the rookie’s usage didn’t budge last week. He landed on Nick Beaudoin’s Week 5 Underperformers list for a reason: only six carries, two catches, 27 total yards, and zero red-zone work. Hard to score when you’re never near the end zone. With Gibson done for the year, the Patriots had a full week to game-plan without him. Fantasy managers are hoping Henderson gets more play. Keyword: Hope. The matchup is fine (Saints rank 22nd vs RBs, allowing 21 PPG), but usage is everything here.
The good news for Rhamondre is he can fumble 20 more times this game and Mike Vrabel still won't play TreVeyon Henderson
— Joe Beldner (@JoeBeldner) October 6, 2025
Verdict: I’m rolling with Michael Carter. The efficiency’s ugly, sure, but “volume is king” in fantasy, and Carter’s got it locked up for now. Henderson’s ceiling could rise with Gibson out, but I’m a “see it to believe it” type of player. Until I actually see the touches and points, he’s staying on my bench.
Derrick Henry or Michael Carter?
This might be the wildest Start/Sit situation of the entire season. King Henry vs Michael Carter in Week 6? What timeline are we in? Derrick Henry was a first-round pick just a few months ago, maybe early second at worst, and now we are seriously debating benching him? Yikes. After an RB1 finish in Week 1, Henry’s fallen off a cliff: RB58, RB22, RB42, and RB25. Without Lamar Jackson and behind a completely wrecked offensive line, he just hasn’t had room to run. And now he faces the Rams, who are the worst possible matchup for RBs. They’re allowing only 13.3 fantasy points per game to the position, best in the league. In other words: don’t expect a rebound here.
Verdict: Start Michael Carter over King Henry. Until Lamar’s back and the Ravens’ line improves, you can’t gamble on Henry. He saw half the carries Carter did last week, and the matchup seals it. Until it snows in Vermont or the Ravens get Lamar back, you can’t gamble with Henry right now.
As we trudge into Week 6, every choice matters. Make sure to continue scouting favorable matchups, stay updated on injuries, and trust your instincts. If you need Start/Sit advice, feel free to drop a comment here or hit me up on X. And don’t forget—Mike’s Sunday show will have you covered all the way up to kickoff. Lastly, don’t forget to utilize the Ballers’ Start/Sit tool and weekly rankings. Now let’s go out there and win those matchups!
from Fantasy Footballers Podcast https://ift.tt/GNh30HX
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